Myocyte growth without physiological impairment in gradually induced rat cardiac hypertrophy.
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چکیده
منابع مشابه
Myocyte growth without physiological impairment in gradually induced rat cardiac hypertrophy.
A surgical technique was developed to place sutures around the pulmonary arteries of young rats (about 1 month old and 100 g body weight). As the operated rats grew, the pulmonary arteries were gradually constricted, leading after 4-6 weeks to the development of severe right ventricular hypertrophy with free wall weights about twice those from control rats. There were no signs of heart failure ...
متن کاملLETTERS TO THE EDITOR Comments on "Myocyte Growth without Physiological Impairment in Gradually Induced Rat Cardiac Hypertrophy"
Precise measurement of the contractile properties of cardiac muscle has been hampered by compliant regions at the ends of the isolated preparation. Eliminating the influence of these regions is especially desirable when the contractile behavior of separate specimens is to be compared, as is done in the elegant study by Julian et al. (1981). While a variety of rather sophisticated approaches to ...
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Endothelin-1 (ET) produces neonatal rat ventricular myocyte (NRVM) hypertrophy and activates focal adhesion kinase (FAK) in other cell types. In the present study, we examined whether ET activated FAK in NRVM and whether FAK was necessary and/or sufficient for ET-induced NRVM hypertrophy. Chronic ET-1 stimulation (100 nM, 48 h) increased protein-to-DNA and myosin heavy chain (MHC)-to-DNA ratios...
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Fibronectin (FN) is an extracellular matrix protein that binds to integrin receptors and couples cardiac myocytes to the basal lamina. Cardiac FN expression is elevated in models of pressure overload, and FN causes cultured cardiac myocytes to hypertrophy by a mechanism that has not been characterized in detail. In this study, we analyzed the gene expression changes induced by FN in purified ra...
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In this study, we evaluated whether blocking myeloid differentiation factor-88 (MyD88) could decrease cardiac myocyte apoptosis following pressure overload. Adenovirus expressing dominant negative MyD88 (Ad5-dnMyD88) or Ad5-green fluorescent protein (GFP) (Ad5-GFP) was transfected into rat hearts (n = 8/group) immediately followed by aortic banding for 3 wk. One group of rats (n = 8) was subjec...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 1981
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.49.6.1300